University of Oxford:
What is the purpose of this research study?
There are now a number of vaccines in the UK that have been approved to prevent COVID-19, and others are expected to be approved in the near future. These use two-doses, a ‘prime’ first dose, followed by a ‘boost’ second dose some weeks later. The purpose of this trial is to see how well people’s immune systems respond when their second “boost” dose is a different type of vaccine to their first “prime” dose. We will also be looking at how common vaccine reactions, such as fever, are after such ‘mixed’ schedules. This is important, as being able to use different vaccines in this way creates a more flexible immunisation programme; potentially allowing more people to be immunised more quickly.
In this study we will be enrolling men and women aged 50 years and over who have already had one dose of a COVID-19 vaccine. We are enrolling from all ethnicities and would particularly welcome participants from the Black, Asian and Minority Ethnic (BAME) community.